Overview of Science and Mission
People Behind the Science
About the People
Terry L. Vanden Hoek, MD
Dr. Terry Vanden Hoek is an Associate Professor in the Department of Medicine at the University of Chicago and currently serves as Interim Chief for the Section of Emergency Medicine. He received his medical degree from the University of Chicago in 1991 and completed his residency training in Emergency Medicine at the University of Cincinnati in 1995. At that time, he returned to the University of Chicago and was a founding member of the Emergency Resuscitation Center when in opened in 1999. He served as co-director of the center from its inception until 2006 when he became sole director.
Dr. Vanden Hoek has received numerous awards in recognition of his outstanding research, including the Society for Academic Emergency Medicine Young Investigator Award in 2001 and the American Heart Association Emergency Cardiovascular Care Programs Leadership Award for 2005-2006 when he was also chair of the American Heart Association Advanced Cardiac Life Support Subcommittee. Currently, Dr. Vanden Hoek is a member of the American Heart Association International Liaison Committee on Resuscitation (ILCOR) Acute Coronary Syndrome Myocardial Infarction Task Force. In addition to these efforts, Dr. Vanden Hoek has also been a reviewer for multiple scientific journals and has served ad-hoc on several NIH study sections.
Dr. Vanden Hoek’s primary research goal is to improve resuscitation strategies for conditions of ischemia and reperfusion, particularly cardiac arrest and hemorrhagic shock. One of the major research projects in his lab examines the role of reactive oxidant species and mitochondrial perturbations in ischemia/reperfusion (I/R) injury. These studies explore the relationship between reperfusion-induced oxidant stress and cell death in both primary cardiomyocytes and murine models of cardiac arrest and hemorrhagic shock. Additionally, his lab has developed cell and animal models that demonstrate hypothermia protection in the context of I/R injury. Several ongoing projects focus on the role of Akt and p38 in mediating this injury and the mechanisms of hypothermia protection. His hope is that this research will lead to the development of alternate therapies that will protect against the post resuscitation injury seen in patients who suffer cardiac arrest or traumatic injury. Dr. Vanden Hoek has produced over 50 peer reviewed publications and has received funding for his work from the National Institutes of Health and the Department of Defense Office of Naval Research.
Selected Representative Publications
Edelson DP, Litzinger B, Arora V, Walsh D, Kim S, Lauderdale DS, Vanden Hoek, TL, Becker, LB and Abella BS: Improving in-hospital cardiac arrest process and outcomes with performance debriefing. Arch Intern Med 168 (10):1063-1069, 2008.
Zhao D, BS Abella, DG Beiser, JP Alvarado, H Wang, KJ Hamann, TL Vanden Hoek, LB Becker. Intra-arrest cooling with delayed reperfusion yields higher survival than earlier normothermic resuscitation in a mouse model of cardiac arrest. Resuscitation 77:242-249, 2008.
Lavani R, Chang WT, Anderson TC, Shao ZH, Wojcik K, Li CQ, Pietrowski R, Beiser DG, Idris AH, Hamann KJ, Becker LB, Vanden Hoek TL. Altering CO2 during reperfusion of ischemic cardiomyocytes modifies mitochondrial oxidant injury. Crit Care Med 35(7):1709-16, 2007.
Shao ZH, Chang WT, Chan KC, Wojcik KR, Hsu CW, Li CQ, Li J, Anderson T, Qin Y, Becker L, Hamann K, Vanden Hoek T. Hypothermia-induced Cardioprotection Using Extended Ischemia and Early Reperfusion Cooling. Am J Physiol (Heart Circ Physiol) (292): H1995-H2003, 2007.
Anderson TC, Li CQ, Shao ZH, Hoang T, Chan KC, Hamann KJ, Becker LB, Vanden Hoek TL. Transient and partial mitochondrial inhibition for the treatment of postresuscitation injury: Getting it just right. Crit Care Med 2006 Dec;34(12 Suppl):S474-S482, 2006.
Abella BS, Zhao D, Alvarado J, Hamann KJ, Vanden Hoek TL, and Becker, LB: Intra-arrest Cooling Improves Outcomes in a Murine Cardiac Arrest Model. Circulation, 109: 2786-2791, 2004.
Vanden Hoek, TL *, Qin,Y *, Wojcik K, Li, CQ, Shao, ZH, Anderson, T, Becker, LB, Hamann, KJ. Reperfusion, not simulated ischemia, initiates intrinsic apoptosis injury in chick cardiomyocytes. Am J Physiol (Heart Circ Physiol) 284(1): H141-50, 2003.
Vanden Hoek TL, Becker LB, Shao Z,Li C, and Schumacker PT. Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes. J Biol Chem 273(29):18092-18098, 1998.